FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to molecular biology, biochemistry and medicine. What is presented is an immunoglobulin conjugate having a lower inclination to cross-linking, containing immunoglobulin including at least one mutation in a residue specified in a group consisting of 7(VH), 20(VL), 22(VL) and 125(CH1); at least one mutation represents a substitution by a cysteine residue, and an atom or molecule; the atom or molecule is conjugated with the cysteine residue, wherein the atom or molecule conjugation with the cysteine residue is directed or mediated, as well as recombinant polynucleotide, expression vector, host cell, pharmaceutical composition, modified immunoglobulin, method for producing immunoglobulin and method for producing immunoglobulin conjugate.
EFFECT: higher effectiveness of the method.
18 cl, 1 tbl, 5 ex
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