FIELD: biotechnology.
SUBSTANCE: humanized antibody to biotin or a biotin binding fragment thereof comprises: HVR-H3 comprising amino acid sequence SEQ ID NO: 11, HVR-H2 comprising amino acid sequence SEQ ID NO: 10, HVR-H1 comprising amino acid sequence SEQ ID NO: 09, HVR-L3 comprising amino acid sequence SEQ ID NO: 15, HVR-L2 comprising amino acid sequence SEQ ID NO: 14, and HVR-L1 comprising amino acid sequence SEQ ID NO: 13. A humanized antibody to biotin or a biotin binding fragment thereof comprising VH sequence SEQ ID NO: 12 and VL sequence SEQ ID NO: 16 is also described.
EFFECT: improved properties.
9 cl, 2 dwg, 3 tbl, 9 ex
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