FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, specifically to a method for preparing conjugates of a therapeutic compound with a prolonged half-life, and can be used in medicine. A conjugate consisting of a therapeutic polypeptide containing 12-dimensional spiral peptide and a specific antibody bound by a disulphide bond is obtained.
EFFECT: invention is used to create pharmaceutical compositions with a prolonged active elimination half-life in vivo.
11 cl, 15 dwg, 4 tbl, 16 ex
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