PYRAZOLOPYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS Russian patent published in 2015 - IPC C07D471/04 A61K31/437 A61P11/00 A61P13/00 A61P17/00 A61P19/00 A61P25/00 A61P27/00 A61P29/00 A61P3/00 A61P35/00 A61P9/00 

Abstract RU 2569303 C2

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry, particularly to a novel pyrazolopyridine derivative of formula (I), as well as to a tautomer, geometric isomer and optically active forms thereof, such as enantiomers, diastereomers and racemates, and to pharmaceutically acceptable salts thereof, where G1 is selected from -C(O)-R1; R1 is selected from C1-C6-alkoxy-C1-C6-alkyl; C1-C6-alkyl; substituted C6-aryl-C1-C6-alkyl; substituted piperidine; G2 is selected from optionally substituted C6-aryl; G3 is selected from C1-C6-alkyl; G4 is selected from pyridine-C1-C6-alkyl; G5 is selected from H; where the term "substituted" denotes groups substituted with one substitute selected from a group which includes "C1-C6-alkyl", "C1-C6-alkoxy", "C1-C6-alkoxycarbonyl" and "halogen". The invention also relates to a specific compound and a pharmaceutical composition based on a pyrazolopyridine derivative.

EFFECT: obtaining novel pyrazolopyridine derivative having the capacity to inhibit NADPH oxidase.

10 cl, 2 tbl, 11 ex

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RU 2 569 303 C2

Authors

Pazh Patrik

Ochard Majk

Lale Benua

Gadzhini Francheska

Dates

2015-11-20Published

2009-09-22Filed