Show metadata Hide metadata

(19)

(11)

2 677 699

(13)

(51)

IPC

C07D487/04(2006-01-01)

A61K31/53(2006-01-01)

(21) (22)

Application

2016126968, 2014-12-08

(24)

Start date

2014-12-08

(22)

Actual filing date

2014-12-08

(45)

Published

2019-01-21

(72)

Inventor

Brukings Daniel KristoferBraun Dzhulien AlisterDzhekson Viktoriya ElizabetPorter Dzhon RobertKuinsi Dzhoanna Rejchel

(73)

Holder

Ucb Biopharma Sprl

IMIDAZOTRIAZINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY Russian patent published in 2019 - IPC C07D487/04 A61K31/53

Abstract RU 2677699 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (IIB) or a pharmaceutically acceptable salt thereof. In formula (IIB), E is -CH₂-; Q represents -CH₂-; Z is hydrogen or methyl; V is N; R¹² is hydrogen; R¹⁵ represents a difluoromethoxy group; R¹⁶ is hydrogen; R²¹ represents hydroxy (C₁-C₆)alkyl and R²³ is hydrogen. Also the invention relates to a pharmaceutical composition, to the use of a compound, to a method for treating and/or preventing rheumatoid arthritis or Crohn's disease.

EFFECT: obtained is a new compound of formula (IIB), which has the properties of a modulator of TNFα activity.

6 cl, 1 ex

Similar patents RU2677699C1

Title	Year	Author	Number
TETRAHYDROBENZIMIDAZOLE DERIVATIVES AS TNF ACTIVITY MODULATORS	2014	Kher Yag Paul Dzhekson Viktoriya Elizabet Kroplin Boris Lekomt Faben Klod Porter Dzhon Robert	RU2684637C1
IMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Dzhekson Viktoriya Elizabet Lekomt Faben Klod Porter Dzhon Robert	RU2683318C1
PURINE DERIVATIVES AS TNF ACTIVITY MODULATORS	2014	Dzhekson Viktoriya Elizabet Kroplin Boris Loue Martin Aleksander Porter Dzhon Robert	RU2684644C1
IMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Dzhekson Viktoriya Elizabet Porter Dzhon Robert	RU2695664C1
CONDENSED TRICYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Alekszander Rikki Piter Braun Dzhulien Alister Delini Mikhael Kher Yag Paul Dzhekson Viktoriya Elizabet Yadot Sofie Kroplin Boris Mak-Koss Malkolm Sabnis Jogesh Anil Svinnen Dominik Lui Leon Van-Khautvin Natali Chzhu Chzhaonin	RU2700004C1
CONDENSED DERIVATIVES OF IMIDAZOLE AND PYRAZOLE AS MODULATORS OF ACTIVITY TNF	2014	Aleksander Rikki Piter Bentli Dzhonatan Mark Brejs Garet Nil Brukings Daniel Kristofer Chovatia Praful Tulshi Debov Erve Zhan Klod Dzhonstoun Krejg Dzhouns Elizabet Perl Kroplin Boris Lekomt Faben Klod Madden Dzhejms Miller Krejg Ejdrian Porter Dzhon Robert Selbi Mattyu Dankan Sho Majkl Alan Vaidya Darshan Gunvant Yule Ajan Endryu	RU2687093C1
PYRAZOLOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Brukings Daniel Kristofer Dzhekson Viktoriya Elizabet Kroplin Boris	RU2684641C1
TETRAHYDROIMIDAZOPYRIDINE DERIVATIVES AS TNF ACTIVITY MODULATORS	2014	Dzhekson Viktoriya Elizabet Kroplin Boris Loue Martin Aleksander Porter Dzhon Robert	RU2684635C1
BENZOTRIAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Brukings Daniel Kristofer Kroplin Boris	RU2677696C1
IMIDAZOPYRIMIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Ali Mezkher Khussejn Brukings Daniel Kristofer Braun Dzhulien Alister Dzhekson Viktoriya Elizabet Kroplin Boris Porter Dzhon Robert	RU2691629C1

RU 2 677 699 C1

Authors

Brukings Daniel Kristofer

Braun Dzhulien Alister

Dzhekson Viktoriya Elizabet

Porter Dzhon Robert

Kuinsi Dzhoanna Rejchel

Dates

2019-01-21—Published

2014-12-08—Filed