Show metadata Hide metadata

(19)

(11)

2 684 637

(13)

(51)

IPC

C07D235/12(2006-01-01)

A61K31/4184(2006-01-01)

A61P3/00(2006-01-01)

A61P9/00(2006-01-01)

A61P25/28(2006-01-01)

A61P27/00(2006-01-01)

A61P29/00(2006-01-01)

A61P35/00(2006-01-01)

A61P37/00(2006-01-01)

(21) (22)

Application

2016126659, 2014-12-08

(24)

Start date

2014-12-08

(22)

Actual filing date

2014-12-08

(45)

Published

2019-04-11

(72)

Inventor

Kher Yag PaulDzhekson Viktoriya ElizabetKroplin BorisLekomt Faben KlodPorter Dzhon Robert

(73)

Holder

Ucb Biopharma Sprl

TETRAHYDROBENZIMIDAZOLE DERIVATIVES AS TNF ACTIVITY MODULATORS Russian patent published in 2019 - IPC C07D235/12 A61K31/4184 A61P3/00 A61P9/00 A61P25/28 A61P27/00 A61P29/00 A61P35/00 A61P37/00

Abstract RU 2684637 C1

FIELD: organic chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to {1-[(2,5-dimethylphenyl)methyl]-4,5,6,7-tetrahydrobenzimidazol-2-yl}(pyridin-4-yl)methanol. Invention also relates to a pharmaceutical composition based thereon, use thereof and a method of treating rheumatoid arthritis and/or Crohn's disease.

EFFECT: technical result: obtaining a novel heterocyclic compound having the properties of a TNFα activity modulator.

4 cl, 1 ex

Similar patents RU2684637C1

Title	Year	Author	Number
PURINE DERIVATIVES AS TNF ACTIVITY MODULATORS	2014	Dzhekson Viktoriya Elizabet Kroplin Boris Loue Martin Aleksander Porter Dzhon Robert	RU2684644C1
IMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Dzhekson Viktoriya Elizabet Lekomt Faben Klod Porter Dzhon Robert	RU2683318C1
IMIDAZOTRIAZINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Brukings Daniel Kristofer Braun Dzhulien Alister Dzhekson Viktoriya Elizabet Porter Dzhon Robert Kuinsi Dzhoanna Rejchel	RU2677699C1
CONDENSED TRICYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Alekszander Rikki Piter Braun Dzhulien Alister Delini Mikhael Kher Yag Paul Dzhekson Viktoriya Elizabet Yadot Sofie Kroplin Boris Mak-Koss Malkolm Sabnis Jogesh Anil Svinnen Dominik Lui Leon Van-Khautvin Natali Chzhu Chzhaonin	RU2700004C1
IMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Dzhekson Viktoriya Elizabet Porter Dzhon Robert	RU2695664C1
CONDENSED DERIVATIVES OF IMIDAZOLE AND PYRAZOLE AS MODULATORS OF ACTIVITY TNF	2014	Aleksander Rikki Piter Bentli Dzhonatan Mark Brejs Garet Nil Brukings Daniel Kristofer Chovatia Praful Tulshi Debov Erve Zhan Klod Dzhonstoun Krejg Dzhouns Elizabet Perl Kroplin Boris Lekomt Faben Klod Madden Dzhejms Miller Krejg Ejdrian Porter Dzhon Robert Selbi Mattyu Dankan Sho Majkl Alan Vaidya Darshan Gunvant Yule Ajan Endryu	RU2687093C1
PYRAZOLOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Brukings Daniel Kristofer Dzhekson Viktoriya Elizabet Kroplin Boris	RU2684641C1
CONDENSED TRICYCLIC BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Aleksander Rikki Piter Kalmiano Mark Daniel Defejs Sabine Dyure Veronik Delini Mikhael Kher Yag Paul Dzhekson Viktoriya Elizabet Keje Zhan Kroplin Boris Mak-Koss Malkolm Sabnis Jogesh Anil Selbi Mattyu Dankan Svinnen Dominik Lui Leon Van-Khautvin Natali Chzhu Chzhaonin Vener Folkmar Khajnelt Uve	RU2689777C1
TETRAHYDROIMIDAZOPYRIDINE DERIVATIVES AS TNF ACTIVITY MODULATORS	2014	Dzhekson Viktoriya Elizabet Kroplin Boris Loue Martin Aleksander Porter Dzhon Robert	RU2684635C1
IMIDAZOPYRIMIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Ali Mezkher Khussejn Brukings Daniel Kristofer Braun Dzhulien Alister Dzhekson Viktoriya Elizabet Kroplin Boris Porter Dzhon Robert	RU2691629C1

RU 2 684 637 C1

Authors

Kher Yag Paul

Dzhekson Viktoriya Elizabet

Kroplin Boris

Lekomt Faben Klod

Porter Dzhon Robert

Dates

2019-04-11—Published

2014-12-08—Filed