PHARMACEUTICAL COMPOSITION, CONTAINING BLOCK-COPOLYMER, INCLUDING BORONIC ACID COMPOUND Russian patent published in 2015 - IPC C08G81/00 A61K31/69 A61P35/00 

FIELD: medicine.

SUBSTANCE: block-copolymer includes hydrophilic segment, including polyethyleneglycol, hydrophobic segment, which includes polyamino acid chain; and boronic acid compound residue, bound with side chain of hydrophobic segment via binding unit, which includes heterocyclic structure. Heterocyclic structure is presented by the following chemical structure: , in which B stands for boron atom, formed by boronic acid compound; R¹, R², R³ and R⁴ each independently stands for hydrogen atom, linear or branched alkyl group with 1-16 carbon atoms, or organic group, containing aromatic group as structure for protection of bond of boronic acid ester, formed by binding of boron atom and oxygen atom, given in chemical structure. The following conditions are observed: (i) at least, one of R¹, R², R³ and R⁴ represents organic structure, containing aromatic group, and (ii) R¹ is not hydrogen atom. Aromatic ring, obtained from aromatic group, is bound with carbon atom, forming cyclic skeleton of heterocyclic structure directly or by means of 1 or 2 atoms.

EFFECT: invention makes it possible to obtain anti-tumour block-copolymer with improved ability of stable support of boronic acid compound in physiological conditions.

4 cl, 4 dwg, 1 tbl, 3 ex