SUBSTITUTED 2-[(1Z)-1-(3,5-DIARYL-1,3,4-THIADIAZOL-2(3H)-YLIDEN)METHYL]-3,5-DIARYL-1,3,4-THIADIAZOL-3-IUM CHLORIDES AND METHOD OF OBTAINING THEREOF Russian patent published in 2015 - IPC C07D417/06 A61K31/433 A61P31/04 

FIELD: chemistry.

SUBSTANCE: invention relates to novel individual compounds of class of mesoionic heterocyclic systems - substituted chlorides of 2-[(1Z)-1-(3,5-diaryl-1,3,4-thiadiazol-2(3H)-ylidene)methyl]-3,5-diaryl-1,3,4-thiadiazol-3-ium of general formula I, where: R = 3,5-diFC₆H₄; R¹ = 4-FC₆H₄ (Ia); R = 4-FC₆H₄; R¹ = Ph (Ib); R = 3,5-diFC₆H₄; R¹ = Ph (Ic); R = 3,5-diClC₆H₄; R¹ = Ph (Id); R = 4-NO₂C₆H₄; R¹ = Ph (Ie); R = Bn; R¹ = Ph (If). Substituted chlorides, presented by formula , are obtained by interaction of substituted N'-arylthiobenzhydrazide with malonyldinitrile in ratio 2:1 in medium of polar organic solvent (demethylformamide) and hydrogen chloride, and reaction mixture is initially saturated by dry hydrogen chloride, and then, without stopping hydrogen chloride supply, heated to 60°C and exposed for an hour with the following product separation. To separate product cooled reaction mixture is poured out on finely-milled ice, mixed and precipitated sediment is filtered out.

EFFECT: obtaining novel compounds which can be applied in medicine as antimicrobial medications, with high output.

3 cl, 5 tbl, 8 ex