SUBSTITUTED 3-ARYL-5-PHENYL-3H-1,2,3,4-DITHIADIAZOLE-2-OXIDES AND THE METHOD OF THEIR PRODUCTION Russian patent published in 2018 - IPC C07D285/01 A61P31/04 

FIELD: chemistry.

SUBSTANCE: invention relates to organic and medical chemistry, namely to compounds of substituted 3-aryl-5-phenyl-3H-1,2,3,4-dithiadiazole-2-oxides of the general formula I, where R=Ph (Ia); R=2-CH₃C₆H₄ (Ib); R=Bn (Ic); R=4-FC₆H₄ (Id); R=4-NO₂C₆H₄ (If); R=3,5-di-FC₆H₄ (Ig). Substituted oxides represented by formula (I) are prepared by reacting a substituted N'-arylthiobenzhydrazide with thionyl chloride, followed by isolation of the desired product. To isolate the desired product, the excess thionyl chloride is distilled off under vacuum at 45 °C and the residue was recrystallized from cyclohexane. .

EFFECT: technical result is the preparation of substituted 3-aryl-5-phenyl-3H-1,2,3,4-dithiadiazole-2-oxides, which can be used in medicine as antimicrobial agents, in high yield.

3 cl, 1 dwg, 8 ex, 9 tbl