FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed invention relates to compounds of formula 
where A1 and R1, R2, R3, R4 and R5 are determined in invention formula, which are preferable inhibitors of cathepsin cycteinprotease, in particular cathepsin S or L cycteinprotease, which makes them useful as medications, especially for treatment of diabetes, atherosclerosis, aneurism of abdominal aorta, peripheral arterial disease or diabetic nephropathy.
EFFECT: invention relates to methods of obtaining claimed compounds, thereof-containing pharmaceutical composition and thereof application.
24 cl, 1 tbl, 255 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | 2010 |
|
RU2535479C2 |
| NOVEL PYRROLIDINE DERIVATIVES | 2017 |
|
RU2736498C1 |
| ETHYLENEDIAMINE DERIVATIVES AND FXa INHIBITOR AND ANTICOAGULANT COMPRISING THEREOF | 2001 |
|
RU2268259C2 |
| CATHEPSIN-CYSTEINE PROTEASE INHIBITORS | 2003 |
|
RU2312861C2 |
| PYRROLIDINE DERIVATIVES APPLICABLE AS CATEPSIN DERIVATIVES | 2011 |
|
RU2548684C2 |
| CATHEPSIN CYSTEINE PROTEASE INHIBITORS | 2014 |
|
RU2692799C2 |
| INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES | 2017 |
|
RU2749547C2 |
| 2-OXA-5-AZABICYCLO[2.2.1]HEPTANE-3-YL DERIVATIVES | 2015 |
|
RU2697651C2 |
| NEW PIPERAZINE AMIDE DERIVATIVES | 2008 |
|
RU2454412C2 |
| NEW AZETIDINE DERIVATIVES | 2013 |
|
RU2629114C2 |
