ETHYLENEDIAMINE DERIVATIVES AND FXa INHIBITOR AND ANTICOAGULANT COMPRISING THEREOF Russian patent published in 2006 - IPC C07D209/12 C07D401/12 C07D417/12 C07D487/04 C07D495/04 C07D498/04 C07D513/04 C07D519/00 A61K31/404 A61P7/02 A61P9/10 

FIELD: organic chemistry, medicine, hematology.

SUBSTANCE: invention elates to new compounds that inhibit activated blood coagulating factor X (Fxa factor) eliciting the strong anti-coagulating effect. Invention proposes compound of the formula (1): Q¹-Q²-C(=C)-N-(R¹)-Q³-N(R²)-T¹-Q⁴(1) wherein R¹, R², Q¹, Q², Q⁴ and T¹ have corresponding values, and Q² represents the group of the formula: wherein R⁹, R¹⁰ and Q⁵ have corresponding values also, or its salt, solvate or N-oxide. Invention provides the development of a novel compound possessing strong Fxa-inhibiting effect and showing the rapid, significant and stable anti-thrombosis effect^{in oral administration.}

EFFECT: valuable medicinal properties of compounds.

13 cl, 1 tbl, 195 ex