FIELD: pharmaceuticals.
SUBSTANCE: invention relates to (2S,4R)-4-[4-(5-methyl-tetrazol-2-yl)-2-trifluoromethyl-benzenesulphonyl]-1-(1-trifluoromethyl-cyclopropanecarbonyl)-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide or a pharmaceutically acceptable salt thereof. Invention also relates to a pharmaceutical composition having cathepsin cysteine protease inhibiting activity based on said compound.
EFFECT: technical result is obtaining a novel compound and a based pharmaceutical composition, which can be used in medicine for treating metabolic diseases mediated by cathepsin S.
6 cl, 70 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | 2010 |
|
RU2535479C2 |
| NEW AZETIDINE DERIVATIVES | 2013 |
|
RU2629114C2 |
| PYRROLIDINE DERIVATIVES APPLICABLE AS CATEPSIN DERIVATIVES | 2011 |
|
RU2548684C2 |
| NOVEL CYCLOPENTANE DERIVATIVES | 2010 |
|
RU2572555C2 |
| PROCESS FOR PREPARATION OF 1-ACYL-4-PHENYLSULFONYLPROLINAMIDE DERIVATIVES AND NEW INTERMEDIATES | 2012 |
|
RU2615997C2 |
| SUBSTITUTED HETEROCYCLIC SULPHONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS | 2014 |
|
RU2675792C2 |
| PYRROLIDINE DERIVATIVES | 2010 |
|
RU2562605C2 |
| PYRROLIDINE DERIVATIVES AS NK-3 RECEPTOR ANTAGONISTS | 2010 |
|
RU2561271C2 |
| 1-[M-CARBOXAMIDO(HETERO)ARYL-METHYL]-HETEROCYCLYL-CARBOXAMIDE DERIVATIVES | 2013 |
|
RU2644761C2 |
| MACROCYCLIC AMIDES AS PROTEASE INHIBITORS | 2013 |
|
RU2625796C2 |
