METHOD OF PRODUCING CARRIER-FREE HIGH-PURITY Lu COMPOUNDS AND CARRIER-FREE Lu COMPOUNDS Russian patent published in 2016 - IPC G21G4/04 G21G4/08 C01F17/00 B01J45/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing carrier-free high-purity ¹⁷⁷Lu compounds for medical purposes and/or diagnostic purposes. A method of producing ⁷⁷Lu compounds from ^l76Yb compounds, irradiated with thermal neutrons, includes loading into a first column, filled with a cation-exchange material, starting materials dissolved in mineral acid and containing ^l77Lu and ¹⁷⁶Yb in an approximate weigh ratio of 1:10² to 1:10¹⁰; replacing protons of the cation-exchange material with ammonium ions using NH₄Cl solution, washing the cation-exchange material with water; connecting the outlet opening of the first column and the inlet opening of a second column; feeding water and a chelating agent into the inlet opening of the first column in order to elute ¹⁷⁷Lu compounds from the first and second columns; determining the level of radioactive radiation at the outlet of the second column to confirm elution of the ¹⁷⁷Lu compounds; collecting the first ¹⁷⁷Lu eluate from the outlet opening of the second column into a vessel; protonating the chelating agent; loading the final column by continuously feeding the obtained ^l77Lu eluate into the inlet opening of the final column; washing off the chelating agent with diluted mineral acid; removing traces of ions of other metals from the ^l77Lu solution by washing the cation-exchange material of the final column with mineral acid in different concentrations and eluting ¹⁷⁷Lu ions from the final column with highly concentrated mineral acid.

EFFECT: invention enables to obtain milligram amounts of carrier-free high-purity ¹⁷⁷Lu compounds.

16 cl, 4 dwg, 1 ex