METHOD OF PRODUCING RADIONUCLIDE LUTETIUM-177 Russian patent published in 2019 - IPC G21G1/06 

FIELD: medicine.

SUBSTANCE: invention relates to a method of producing radionuclide ¹⁷⁷Lu without a carrier for use in nuclear medicine. Method comprises irradiating target containing ¹⁷⁶Yb, neutron flux in nuclear reactor, in irradiation by reaction ¹⁷⁶Yb(n,γ)^I77Yb (1.9 h) β-→^I77Lu in target creates target isotope ¹⁷⁷Lu, which is then separated from ytterbium, first depositing ytterbium in the form of ytterbium sulphate by contacting the ytterbium sulphate solution and ¹⁷⁷Lu and sodium amalgams, while stirring and dropping amalgam, with cleaning solution from precipitate, after that, translating ¹⁷⁷Lu and the remaining ytterbium in the acetic acid solution and performing successive contact reduction operations with drop-by-drop supply of amalgam and mixing to reduce loss of lutetium, a low-boiling solvent which is immiscible with working solutions is added to the cell.

EFFECT: obtaining isotope ¹⁷⁷Lu in practically significant amounts (tens of curies) when using nuclear reactors with average neutron flux of ~10¹⁴ n⋅cm^-2⋅c^-1.

4 cl, 1 tbl, 1 ex