QUINOLYL-CONTAINING COMPOUND OF HYDROXAMIC ACID, METHOD FOR THEREOF OBTAINING AND APPLICATION IN TREATMENT OF DISEASES, CAUSED BY ABNORMAL PROTEINKINASE AND/OR HYSTONE DEACETYLASE ACTIVITY Russian patent published in 2016 - IPC C07D401/12 C07D215/233 A61K31/47 A61K31/4709 A61P35/00 A61P35/02

Abstract RU 2573633 C2

FIELD: chemistry.

SUBSTANCE: claimed invention relates to field of organic chemistry, namely to novel quinolyl-containing compounds of hydroxamic acid of general formula (I), wherein each of V¹ and V² independently represents halogen; one of R and R' represents group Q, containing hydroxamic acid, and the other represents methoxy, wherein group Q, containing hydroxamic acid, is represented by formula ; A represents O; L represents C_1-6alkyl; J represents NH, piperidinyl, or J is absent; X is absent; Y represents C_1-6alkyl, or Y is absent. The invention also relates to method for obtaining formula (I) compound, pharmaceutical composition, based on formula (I) compound and its application for treatment of diseases, caused by proteinkinase and/or histone deacetylase activity.

EFFECT: novel compounds, which can be applied in cancer treatment, have been obtained.

25 cl, 7 dwg, 7 tbl, 45 ex

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RU 2 573 633 C2

Authors

Jun' Tszyvehj

Van Khontao

Dates

2016-01-27—Published

2011-09-27—Filed