PHARMACEUTICALLY ACTIVE COMPOUNDS AS Axl INHIBITORS Russian patent published in 2016 - IPC C07D401/12 C07D401/14 C07D413/12 C07D413/14 C07D417/12 C07D417/14 A61K31/4709 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a compound of structural formula (I) possessing inhibitory activity on the TAM family of receptor tyrosine kinases (RTKs). In formula (I) A represents C-R¹⁰; B represents C-R¹¹, N; R¹, R⁴ are independently specified in -H, -F, -Cl, -Br, -I, -OH, -NH₂, -OCH₃, -OC₂H₅, -OC₃H₇, -OCH(CH₃)₂, -NO₂, -CHO, -COCH₃, -COC₂H₅, -COC₃H₇, -O-cyclo-C₃H₅, -OCH₂-cyclo-C₃H₅, -O-C₂H₄-cyclo-C₃H₅, -OCF₃, -OC₂F₅, -CH₂F, -CHF₂, -CF₃, -CH₂Cl, -CH₂Br, -CH₂I, -CH₂-CH₂F, -CH₂-CHF₂, -CH₂-CF₃, -CH₂-CH₂Cl, -CH₂-CH₂Br, -CH₂-CH₂I, cyclo-C₃H₅, -CH₂-cyclo-C₃H₅, -CH₃, -C₂H₅, -C₃H₇, -CH(CH₃)₂, -C₄H₉, -CH₂-CH(CH₃)₂, -CH(CH₃)-C₂H₅, -C(CH₃)₃, -CH=CH₂, -CH₂-CH=CH₂, -C(CH₃)=CH₂, -CH=CH-CH₃; R² are R³ are independently specified in -O-R¹⁸, -O-CR⁷³R⁷⁴-R¹⁸, -O-CR⁷³R⁷⁴-CR⁷⁵R⁷⁶-R¹⁸, -O-CR⁷³R⁷⁴-CR⁷⁵R⁷⁶-CR⁷⁷R⁷⁸-R¹⁸, -O-CR⁷³R⁷⁴-CR⁷⁵R⁷⁶-CR⁷⁷R⁷⁸-CR⁷⁹R⁸⁰-R¹⁸; R⁵ and R⁶ represent -H; R⁷, R⁸, which can be identical or different from each other, represent -H, -F, -Cl, -Br, -I, -CN, -NO₂, -CH₃, -C₂H₅, -C₃H₇, -CH(CH₃)₂, cyclo-C₃H₅, -CH₂-cyclo-C₃H₅, -OCH₃; R⁹ represents -H. The radical values D, R¹⁰, R¹¹, R¹⁸, R^73-R⁸⁰ are presented in the patent claim. The invention also refers to a pharmaceutical composition containing the above compound.

EFFECT: producing the compounds possessing the inhibitory activity on the TAM family of receptor tyrosine kinases (RTKs).

14 cl, 3 tbl, 106 ex