ANTI-CXCR4 ANTIBODIES AND USING THEM FOR TREATING CANCER Russian patent published in 2016 - IPC C07K16/28 C12N5/12 C12P21/08 A61K39/395 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to immunology. There are presented version recovered anti-CXCR4-antibodies 414H5, 515H7 and their antigen-binding fragments able to inhibit CXCR4 activation, wherein each antibody or its antigen-binding fragment comprises a set of 6 CDRs sequences of which are presented in the description. There are described: nucleic acid coding the above antibody, a vector for producing the anti-CXCR4-antibody and a host cell producing the above anti-CXCR4-antibody and transfected by the above vector. What is presented is a method for producing the anti-CXCR4-antibody or its antigen-binding fragment according to the present invention, involving: culturing the above host cell in a medium in the respective culture environment; and recovering the above antibody or one of its functional fragments. What is disclosed is a pharmaceutical composition containing as an active ingredient the above antibody or its functional fragments in an effective amount, as well as an excipient and/or pharmaceutically acceptable carrier.

EFFECT: invention enables producing the anti-CXCR4-antibody modulating spatial conformation of CXCR4/CXCR4 and CXCR2/CXCR4 dimers in cancer diseases.

23 cl, 23 dwg, 5 tbl, 24 ex