FIELD: chemistry.
SUBSTANCE: group of inventions relates to specifically binding CD20 antibodies, which contain variable region of light chain and variable region of heavy chain, where CDR1, CDR2 and CDR3 of said variable region of light chain contain amino acid sequences SEQ ID NO: 17-19 or SEQ ID NO: 25-27 and where CDR1, CDR2 and CDR3 of said variable region of heavy chain contain amino acid sequences SEQ ID NO: 20-22 or SEQ ID NO: 28-30, their conjugates with cytotoxic agents, as well as to their application in treatment of autoimmune and inflammatory diseases, and malignant neoplasms.
EFFECT: antibodies in accordance with the group of the inventions possess specificity, reduced toxicity, stability and improved physical and functional properties in comparison with known therapeutic agents.
16 cl, 36 dwg, 1 tbl, 20 ex
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