FIELD: biochemistry.
SUBSTANCE: invention relates to an antibody or its antigen-binding fragment specifically binding to CD37, as well as to an immunoconjugate thereof, a diagnostic reagent and a pharmaceutical composition. Also disclosed is an isolated cell producing said antibody or antigen-binding fragment thereof, which is a hybrid of ATCC number PTA-10664, deposited in ATCC on February 18, 2010, as well as an isolated polynucleotide, coding a heavy chain variable region and a light chain variable region of said antibody or antigen-binding fragment thereof. Invention also relates to use of an antibody or antigen-binding fragment thereof, as well as to use of the immunoconjugate in the manufacture of a medicament for the treatment of an oncological disease characterized by the presence of CD37-expressing cells.
EFFECT: invention enables effective treatment of oncological disease characterized by the presence of CD37-expressing cells.
33 cl, 32 dwg, 12 tbl, 17 ex
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