INTRINSICALLY MAGNETIC HYDROXYAPATITE Russian patent published in 2016 - IPC A61L27/12 C01B25/32 C01B25/45 A61P19/00 B82B1/00 

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, more specifically to hydroxyapatite doped with Fe²⁺ ions and Fe³⁺ ions which partially substitute calcium ions in a crystalline lattice Hydroxyapatite is characterized by an intrinsic magnetism from 0,05 to 8 emu/g measured in an applied magnetic field of 34 Oe, due to the presence of magnetic nano-domains in the HA crystalline lattice with a limited amount of magnetic secondary phases making less than approximately 3 vol % The intrinsically magnetic hydroxyapatite can be loaded with biological substances specified in a group consisting of proteins, genes, stem cells, growth factors and vascularisation factors, active substances and medicinal products, under the control of an external magnetic field, as a delivery and release agent for biological substances or medicinal products, as a contrast agent in diagnostics or for bone or osteochondral regeneration.

EFFECT: hydroxyapatite provides delivery and release of medicinal products with providing a controlled release rate and selectivity.

15 cl, 11 dwg, 5 tbl, 3 ex.