METHOD FOR OBTAINING INTERMEDIATE ERTAPENEM COMPOUND Russian patent published in 2016 - IPC C07D477/20

Abstract RU 2575979 C2

FIELD: chemistry.

SUBSTANCE: invention relates to field of organic chemistry, namely to method for obtaining intermediate ertapenem compound of formula

in solid form, in which Np represents or and P₁ and P₂ represent protective groups for carboxyl; in which when Np represents , P₁ and P₂ both represent p-nitrobenzyl, o-nitrobenzyl, p-methoxybenzyl, allyl, 2,2,2-trichloroethyl, benzhydryl, trimethylsilyl or tert-butyl; when Np represents , P₁ represents p-nitrobenzyl; with method including condensation of initial carbapenem core of formula with side chain of ertapenem of formula ; in accordance with the invention reaction mixture is poured into acid solution after reaction termination.

EFFECT: novel method for obtaining intermediate compound 2a, characterised by simplicity, efficiency and environmental friendliness.

8 cl, 1 dwg, 3 tbl, 24 ex

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RU 2 575 979 C2

Authors

Shi In

Li Kun'

Se Tszan'

Chzhao Sjuehbin'

Lv Tszjan'

Juj Sjutsin'

Dates

2016-02-27—Published

2010-04-30—Filed