FIELD: medicine, pharmacy.
SUBSTANCE: invention describes a combination used in therapeutic, prophylactic or palliative treatment of pain. Proposed combination consists of the following components: (a) alpha-2-delta ligand chosen from habapentine, prehabaline, [(1R,5R,6S)-6-(aminomethyl)bicyclo[3.2.0]hept-6-yl]acetic acid, 3-(1-aminomethylcyclohezylmethyl)-4H-[1.2.4]oxadiazol-5-one, C-[1-(1H-tetrazol-5-ylmethyl)cycloheptyl]methylamine, (3S,4S)-(1-aminomethyl-3,4-dimethylcyclopentyl)acetic acid, (1α,3α,5α)-(3-aminomethylbicyclo[3.2.0]hept-3-yl)acetic acid, (3S,5R)-3-aminomethyl-5-methyloctanoic acid, (3S,5R)-3-methylheptanoic acid, (3S,5R)-3-amino-5-methylnonanoic acid and (3S,5R)-3-amino-5-methyloctanoic acid, or pharmaceutically acceptable salts of any of them, and (b) S,S-reboxetine or its pharmaceutically acceptable salt wherein alpha-2-delta ligand and S,S-reboxetine are taken in the range of ratio from 1:10 to 10:1 of mass parts. Proposed combination provides decreasing the dose of each substance that results to declining adverse effects and enhancing clinical utility of compounds. Also, invention describes using this combination and a set comprising this combination.
EFFECT: improved, enhanced and valuable properties of combinations.
8 cl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMBINATIONS OF ALPHA-2-DELTA-LIGAND WITH SELECTIVE CYCLOIXYGENASE-2 INHIBITOR | 2003 |
|
RU2286151C2 |
| ALPA-2-DELTA LIGAND FOR LOWER URINARY TRACT SYMPTOMS TREATMENT | 2003 |
|
RU2331438C2 |
| SALTS AND CRYSTALLINE FORMS | 2014 |
|
RU2654855C2 |
| METHOD OF TREATMENT OF DISEASES AT MAMMALS | 2004 |
|
RU2344121C2 |
| PREGABALIN DERIVATIVES FOR HOT FLUSH TREATMENT | 2003 |
|
RU2353358C2 |
| BICYCLIC GAMMA AMINO ACID DERIVATIVE | 2008 |
|
RU2446148C2 |
| POLYMORPHIC FORMS | 2014 |
|
RU2670978C9 |
| THE SELECTIVE INVERSE AGONISTS OF SEROTONIN RECEPTORS AS MEDICATION TO CURE DISEASES | 2005 |
|
RU2442607C2 |
| GAMMA-AMINOBUTYRIC ACID (GABA) ANALOGUES FOR TREATMENT OF PAIN AND OTHER DISORDERS | 2014 |
|
RU2679407C1 |
| 4-[2-(2-FLUOROPHENOXYMETHYL)PHENYL]PIPERIDINE COMPOUNDS | 2009 |
|
RU2515612C2 |
