FIELD: medicine.
SUBSTANCE: for vascular dystonia simulation in rats by hypertensive type, Wistar male rats intraperitoneally receives multiply modified low density lipoproteins, prepared from the blood serum of patients with carotid arteries atherosclerosis at a dose of 200 mcg in terms of protein. The development of hypotonic type vascular dystonia is ascertained with a steady decrease in blood pressure down to 80-85 mm Hg.
EFFECT: method provides creation of an easily-replicated, simple and rapid dystonia model in rats, which can be used both in basic research of endothelial dysfunctions and for screening of drugs with endothelium protective action.
1 ex, 5 dwg
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