METHOD OF PRODUCING NANOCAPSULES OF L-ARGININE AND NORVALINE IN SODIUM ALGINATE Russian patent published in 2016 - IPC A61K9/51 B82B3/00 B01J13/06 A61K31/198 

Abstract RU 2579608 C1

FIELD: pharmaceutics.

SUBSTANCE: invention relates to chemical-pharmaceutical industry and represents method of encapsulating preparation via a non-solvent addition differing by fact that cores of nano capsules is L-arginine or norvaline, envelope is sodium alginate at ratio shell:nucleus 3:1 or 1:5. At that, L-arginine or norvaline slowly added in portions to sodium alginate suspension in butanol in presence of preparation E472c as surfactant, with mixing 1,000 rpm; then hexane is added and obtained suspension is filtered and dried at room temperature.

EFFECT: invention provides simplifying and accelerating process of producing nano capsules and increases mass output.

1 cl, 1 dwg, 5 ex

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RU 2 579 608 C1

Authors

Krolevets Aleksandr Aleksandrovich

Bogachev Ilja Aleksandrovich

Dates

2016-04-10Published

2014-09-22Filed