METHOD FOR DRUG DELIVERY TO POSTERIOR EYEBALL SEGMENT STRUCTURES Russian patent published in 2016 - IPC A61F9/07 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to ophthalmology, and can be used to deliver drugs to structures of posterior segment of eyeball. Producing through puncture of eyeball membranes 27G port at a distance of 4.0 mm from limbus toward equator of eyeball in upper-outer quadrant. Straight cannula 27G, implant comprising, carried out in vitreal cavity depth mid vitreous to lens implant is introduced in upper third of vitreous cavity, cannula 27G is removed directly, 27G port is removed, performing subconjunctival injection of 0.4 ml of 1.5 % dexamethasone. Implant is a biodegradable polymer, layers which are homogeneously distributed in drug substance, layers of implant are formed as congruent to each other ellipsoids of revolution consisting of polymers and/or copolymers of glycosaminoglycans, lactic acid and polyvinylpyrrolidone and layers, saturated drug substance, alternated with layers, not saturated drug substance; solubility of each layer of implant is provided by hydrolysis of crosslinks and directly proportional to their number; multilayer biodegradable implant diameter is from 0.03 to 0.3 mm.

EFFECT: invention improves functional results of treatment of various vitreoretinal diseases due to controlled drug release in therapeutic concentration in a given period of time.

1 cl, 1 ex