FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine and to a method of treating and/or preventing diabetes by preventing destruction of β-cells of pancreatic islets, wherein said method comprises administering to a patient in need thereof an effective amount of a antisense oligonucleotide against SMAD7 or a pharmaceutically acceptable salt thereof. Group of inventions also relates to a method for promoting survival of pancreatic islet cells after transplantation. It also relates to a method for preventing hyperglycemia by preventing destruction of β-cells of pancreatic islets.
EFFECT: group of inventions provides the prevention of destruction of β-cells of pancreatic islets.
20 cl, 3 ex, 7 dwg
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