FIELD: biotechnology.
SUBSTANCE: following is described: a group of inventions including a pharmaceutical composition for treating a tumor in a subject and a kit for treating a tumor in a subject. The pharmaceutical composition contains a therapeutically effective amount of an exosome, a therapeutically effective amount of an oncolytic herpes simplex virus and a pharmaceutically acceptable carrier, wherein the exosome contains an inhibitory amount of a CTLA4-targeting siRNA and an exomotif operably linked to a seed sequence of the CTLA4-targeting siRNA to improve packaging of the CTLA4-targeting siRNA into ezkosome, and wherein the oncolytic herpes simplex virus expresses an immunostimulating agent or both an immunostimulating agent and an anti-PD-1 antibody.
EFFECT: invention expands the arsenal of agents for treating tumors in a subject.
40 cl, 3 dwg, 2 tbl, 1 ex
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