MODIFIED IMMUNOMODULATING PARTICLES Russian patent published in 2016 - IPC A61K9/54 A61P37/00 

FIELD: medicine.

SUBSTANCE: group of inventions concerns methods of reducing duration or severity of the inflammatory immune response in an individual, as well as a pharmaceutical composition containing carboxylated particles. Whereupon attached biologically active substances or attached antigenic molecules in the above particles are absent. Particles are particles of polylactic-co-glycolic acid (PLGA), polystyrene particles or diamond particles. Diameter of said particles is between approximately 0.1 mcm to approximately 10 mcm. Individual can have an autoimmune disorder, such as multiple sclerosis, scleroderma, type I diabetes, rheumatoid arthritis, thyroiditis, systemic lupus erythematosus, Reynaud syndrome, Sjogren's syndrome, autoimmune uveitis, autoimmune myocarditis or Crohn's disease, has ischemic reperfusion injury, atherosclerosis, suffered from myocardial infarction, is recipient of transplant, has psoriasis or dermatitis, or suffers from allergic disorders, such as eczema, asthma, allergic rhinitis or skin hypersensitivity. Individual can have a viral or bacterial infection, which can induce development of encephalitis or meningitis.

EFFECT: group of inventions provides reduction or elimination of inflammatory, immune response in an individual without the need to attach any biologically active substances, antigens to particles.

12 cl, 13 dwg, 7 ex