FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology. Disclosed virus-like particle (VLP) for use in producing an immunogenic composition for protection against human cytomegalovirus-related disease, involving: first polypeptide, which is a mouse leukemia virus (MLV) gag polypeptide, the amino acid sequence of which exhibits at least 85 % identity with a self-assembling portion of the original MLV gag protein having the amino acid sequence SEQ ID NO: 1; and a second polypeptide comprising a human cytomegalovirus (HCML) glycoprotein B (gB) protein having a transmembrane domain which is not naturally detectable in gB; wherein said second polypeptide has the amino acid sequence SEQ ID NO: 10. Disclosed is a pharmaceutical composition for protection against human cytomegalovirus disease containing a therapeutically effective amount of the described VLP and a pharmaceutically acceptable excipient.
EFFECT: invention extends the range of cytomegalovirus control agents.
5 cl, 14 dwg, 4 tbl, 7 ex
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