FIELD: medicine, pharmaceutics.
SUBSTANCE: presented invention refers to biotechnology, namely a virus-like particle (VLP) applicable in vaccines or antigenic compositions for treating or preventing rabies virus (RV) infection, as well as methods for producing and using them. The virus-like particle contains one or more RV glycoproteins (G proteins), wherein G proteins are presented in the form of a micella and form a trimmer, and wherein the above micelle contains the detergent nonylphenol ethoxylate 9 (NP-9).
EFFECT: presented invention enables the high-effectiveness treatment or prevention of the rabies virus infection.
21 cl, 6 dwg, 2 tbl, 5 ex
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