FIELD: medicine.
SUBSTANCE: group of inventions refers to medicine, namely immunology and can be used for treating immunological disturbances. According to the invention tolerogenic composition comprises polystyrene carrier particle, carboxylated polysterene carrier particle, carrier particle of lactic and glycolic acids copolymer or a carboxylated carrier particle of lactic and glycolic acids copolymer, wherein this particle has a negative zeta potential and contains an encapsulated antigen. According to the invention the method comprises administering to the subject an effective amount of a tolerogenic composition.
EFFECT: use of inventions allows strengthening the antigen-specific tolerance in a subject by its stimulation with negatively charged particles of the lactic and glycolic acids copolymer.
25 cl, 39 dwg, 1 tbl, 22 ex
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