N-HETEROCYCLIC DERIVATIVES AND THEIR APPLYING AS NITROGEN OXIDE SYNTHASE INHIBITOR Russian patent published in 2004 - IPC

FIELD: organic chemistry, biochemistry.

SUBSTANCE: invention relates to new N-heterocyclic derivatives of the formula (I):

wherein A means -OR¹, -C(O)N(R¹)R² or -N(R¹)R²¹; each among X, Y and Z means independently nitrogen atom (N) or C(R¹⁹); each U means nitrogen atom (N) or C(R⁵) under condition that U means N only when X means N, and Z and Y mean CR¹⁹; each W means N or CH; V means: (1) N(R₄); (2) C(R₄)H or (3) group bound directly with group -C(R¹⁴)(R²⁰)_n-A wherein means 5-6-membered N-heterocycle optionally comprising additional heteroatom in 6-membered ring^{taken among oxygen, sulfur atom and NR6 wherein R6 means hydrogen atom, optionally substituted phenyl, 6-membered heterocycle comprising 1-2 nitrogen atoms optionally substituted with 5-membered heterocyclyl comprising 1-2 nitrogen atoms, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, (C₁-C₆)-alkoxycarbonyl, acetyl and others.}

EFFECT: valuable biochemical properties of compounds.

44 cl, 7 dwg, 7 tbl