METHOD AND APPARATUS FOR PRODUCING SERUM WITH THROMBIN FROM ONE DONOR Russian patent published in 2016 - IPC A61M1/36 A61M37/00 A61K35/16 A61K35/14 A61K38/36 A61P7/04 

FIELD: medicine.

SUBSTANCE: group of inventions relates to transfusion medicine. Serums with thrombin are produced. For this purpose liquid blood sample is obtained, having first aliquot of liquid blood with procoagulant to make prothrombinaze enzyme complex associated with surface of procoagulant agent, which enables to obtain activated procoagulant agent, which can be stored. Activated procoagulant agent then may be subjected to interaction with second liquid blood aliquot containing prothrombin to obtain serum with Thrombin, which can be extracted and subjected to interaction with fibrinogen for preparing fibrin. To obtain serum with Thrombin special device is used containing reaction chamber with one or several compartments to hold procoagulant agent and liquid part of blood without flow. Procoagulant agent can reaction with said liquid part of blood to form fibrin gel, appliances to feed fluid into and from reaction chamber, means to retain solid particles in reaction chamber; agent for serum separation with Thrombin from fibrin gel. Further, device also comprises ventilation hole made with possibility of avoiding long period of staying under excessive pressure of reaction chamber. At that, one or several solid floating objects are present in reaction chamber, wherein solid loose objects, have diameter within range of 50 mcm and 2 mm, and other solid loose objects are characterised by dimensions selected for grinding of fibrin gel, and in cross section have, at least 4 mm.

EFFECT: group of inventions allows eliminating risk of toxic reaction in patient in response to introduction of serum with Thrombin, risk of immunogenic reactions and risk of infectious diseases transmission from donors.

25 cl, 8 dwg, 2 tbl