ABIRATERONE ACETATE FORMULATION Russian patent published in 2020 - IPC B02C19/00 B02C19/16 A61K9/14 A61K9/20 A61K31/573 A61K31/58 C07J43/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: group of inventions relates to the pharmaceutical industry, more specifically to a method of producing a composition containing nanoparticles of abiraterone acetate, and to a method for preparing a solid oral composition based thereon. Also disclosed is a pharmaceutical composition and a solid oral pharmaceutical composition containing: abaraterone acetate; ground grinding material; grinding agent selected from colloidal silica, surfactant, polymer, stearic acid and derivatives thereof; an antioxidant selected from ascorbic acid, butylated hydroxyanisole and butylated hydroxytoluene; and a binding agent selected from fumaric, tartaric and citric acids, where [D₉₀] of the particles of abiraterone acetate is more than 100 nm and less than 1000 nm. Also disclosed are embodiments of a method of treating castration-resistant prostate cancer.

EFFECT: group of inventions provides improved profile of dissolving abiraterone acetate, as well as high stability of composition based on it by reducing oxidative degradation of active agent.

13 cl, 7 ex, 4 tbl, 8 dwg