IAP INHIBITORS Russian patent published in 2016 - IPC C07D417/14 C07K5/83 A61K31/427 A61K38/06 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula I, where Ph is phenyl; R¹ represents C_3-7cycloalkyl; each R², R³, R⁴, R⁵ and R⁶ independently in each case is H or C_1-6alkyl; or a pharmaceutically acceptable salt thereof. Invention also relates to a compound which is (2-oxazol-2-yl-4-phenylthiazol-5-yl)amide (S)-1-[(S)-2-cyclohexyl-2-((S)-2-methylaminopropionylamino)acetyl]-pyrrolidine-2-carboxylic acid (Ia) or a pharmaceutically acceptable salt thereof. Compounds of formula I and Ia are intended for preparing a pharmaceutical composition for treating cancer, containing a compound in an effective amount and at least one pharmaceutically acceptable carrier, diluent or excipient.

EFFECT: technical result is inhibitors of IAP proteins suitable for treatment of cancer.

8 cl, 2 dwg, 8 ex