FIELD: pharmaceutics.
SUBSTANCE: invention relates to a crystalline compound levoisovalerylspiramycin I, characterised by chemical structural formula (I)
with fusion temperature 116~122 °C and X-ray powder diffraction crystalline compound levoisovalerylspiramycin I measured using radiation of Cu-Kα, with characteristic peaks at 2θ = 7.6°, 8.0°, 10.0°, 11.4°, 16.4°, 17.0°, 17.5°, 17.9°, 19.5°, 22.7°, 23.7° and 24.4°; composition for treating infectious diseases, as well as a method of preparing said compound, which involves dissolving solid connection levoisovalerylspiramycin I in mixed solution of ethyl acetate, absolute ethyl alcohol and anhydrous acetone, adding distilled water while stirring mixture, cooling to 5 °C-15 °C after adding distilled water, continuation of mixing during cooling, then obtaining crystalline compound levoisovalerylspiramycin I, wherein volume ratio of ethyl acetate, absolute ethyl alcohol and anhydrous acetone in mixed solvent is 1:0.1-10:0.5-1.
EFFECT: novel crystalline substance, effective for treating bacterial infections.
14 cl, 56 ex, 10 tbl, 7 dwg
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