FIELD: medicine.
SUBSTANCE: invention relates to crystalline levoisovaleryl spiramycin III of formula (I), its use in medicine and the process for its preparation
(1),
characterized by a melting point of 116–118 °C and X-ray diffraction, measured by Cu-Kα radiation with peaks at 2θ = 8.0°, 10.0°, 11.2°, 11.7°, 16.4°, 19.1°, 19.6°, 20.0°, 21.4°, 22.9°, 23.6° and 29.4°; while dissolving said compound in chloroform at 25 °C and a concentration of 0.02 g/ml optical rotation angle [α]D is (-49) – (-51)°. Proposed method involves dissolving levoisovaleryl spiramycin III in a mixture of absolute methyl alcohol, absolute ethyl alcohol and anhydrous acetone in a ratio of 1:0.1 – 10:0.5–1, adding distilled water during stirring, cooling to 5–15 °C to obtain crystalline compound III.
EFFECT: new efficient method of obtaining a new crystalline form is proposed, which can be effectively used to prepare an agent for the treatment and/or prevention of infectious diseases.
19 cl, 56 ex, 5 dwg, 10 tbl
| Title |
Year |
Author |
Number |
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2011 |
|
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|
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|
RU2766176C2 |
| BIOSYNTHETIC GENE CLUSTER OF CARRIMYCIN |
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| METHOD OF PREPARING DERIVATIVES OF 7-/2-(2-AMINO-4-THIAZOLYL)-2-ALKOXYMINOACETAMIDO/-3-3(1,2,4-THIADIAZOL-5-YLTHIOMETHYL)CEPH-3-EM-4-CARBOXYLIC ACID OR THEIR SALTS WITH ALKALINE METALS IN THE FORM OF SIN-ISOMERS |
0 |
|
SU841590A3 |
