LEVOISOVALERIL SPIRAMYCIN II, PREPARATIONS, METHOD OF PREPARATION AND USE Russian patent published in 2018 - IPC C07H17/08 C12P19/62 A61K31/7048 A61P31/04 A61P31/10 

FIELD: pharmaceutical industry.

SUBSTANCE: invention relates to the preparation and use in the pharmaceutical industry of crystalline levoisovaleril spiramycin II of formula (I):

characterized by the melting point of 120–128 °C and X-ray diffraction, measured using Cu-K radiationα with peaks at 2θ = 10.0°, 11.6°, 16.4°, 17.3°, 19.1°, 21.2°, 22.1°, 22.7°, 26.4°, 26.9°, 27.5° and 31.5°, whereby dissolving said crystalline compound in chloroform at 25 °C and a concentration of 0.02 g/ml optical rotation angle [α]_D is -55° – 61°. A method for the preparation of said crystalline compound comprises dissolving the solid levoisovaleril spiramycin II in a mixture of absolute methyl alcohol, anhydrous acetone and absolute ethyl alcohol in a ratio of 1: 0.1–10:0.5–1, adding distilled water with stirring, cooling to 5–15 °C to obtain the said crystallographic compound of levoisovaleril spiramycin II.

EFFECT: new effective method of obtaining a new crystalline form is introduced, suitable for the effective preparation of drug anti-infectious agents is proposed.

19 cl, 5 dwg, 56 ex, 10 tbl