PRODRUGS CONTAINING INSULIN LINKER CONJUGATE Russian patent published in 2016 - IPC A61K38/28 A61K47/48 A61P3/10 

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to insulin linker conjugate D-L or its pharmaceutically acceptable salt, wherein D represents an insulin fragment and -L is a biologically inactive linker fragment -L¹ presented by formula (I), wherein a dash line indicates an attachment point to one of insulin amino groups by forming an amide bond. The invention also refers to pharmaceutical compositions containing the above conjugates, methods for producing, as well as using them as a medicinal product for treating or preventing diseases or disorders which may be treated by insulin.

EFFECT: group of inventions provides reducing a rate of injections and making it possible to provide optimum control of blood insulin and glucose.

65 cl, 21 ex, 9 dwg