DIAGNOSIS, PREVENTION AND TREATMENT OF JOINT DISEASES Russian patent published in 2019 - IPC A61K47/50 A61P19/02 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: use of a polymeric prodrug is proposed that is a D-L conjugate for intra-articular injection to treat joint diseases, where D is a biologically active fragment containing a primary or secondary amine, and L is a biologically inactive linker fragment L¹ of Formula (VII), with L¹ substituted by one group L²-Z where L² is a single chemical bond or spacer and where Z is a water-insoluble hydrogel based on polyethylene glycol (PEG) and hyaluronic acid. There are also proposed a pharmaceutical composition comprising said polymeric prodrug together with one or more pharmaceutically acceptable excipients, and a method of treating a disease of the joints by administering a therapeutically effective amount of said polymeric prodrug or said pharmaceutical composition.

EFFECT: group of inventions provides therapy of joint diseases by intra-articular injection.

9 cl, 22 ex, 1 dwg