ESSENTIALLY NON-TOXIC MUTEIN OF Clostridium perfringens ALPHA TOXIN AND NUCLEIC ACID MOLECULE CODING SAME Russian patent published in 2016 - IPC C12N15/31 C07K14/33

Abstract RU 2593945 C2

FIELD: biotechnology.

SUBSTANCE: expressed alpha toxin and a nucleic acid molecule coding it are a deletion mutein, which in comparison to mature alpha toxin Clostridium perfringens strain 13 is deprived of at least nine sequential amino acid residues, including His₆₈, but retains significant antigenicity of toxin.

EFFECT: invention can be used as a vaccine against Clostridium perfringens.

6 cl, 3 tbl, 5 ex

Similar patents RU2593945C2

Title	Year	Author	Number
RECOMBINANT ATTENUATED MICROORGANISMS CLOSTRIDIUM AND VACCINE	2007	Kokrehn Mark D. Petersen Gehri Lehjr Stiven V. Sinenki Richard	RU2445364C2
CLOSTRIDIAL TOXIN NetB	2008	Mur Robert Dzhon Rud Dzhulian Ian Kibern Ehntoni Lesli	RU2474587C2
COMPOSITION FOR PIGS PROTECTION AGAINST PRRS-VIRUS INFECTION (VERSIONS) AND VACCINE CONTAINING SPECIFIED COMPOSITION (VERSIONS)	2006	Jo Dongvan Li Changkhi Kalvert Dzhej Gregori Uolch Sjao-Kun	RU2381035C2
NORTH AMERICAN PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS) VIRUS AND USES THEREOF	2011	Welch Siao-Kun Wan Calvert Jay Gregory Slade David Ewell	RU2592667C2
LIVE ATTENUATED Pasteurella multocida BACTERIUM, BASED VACCINE, METHOD FOR MAKING VACCINE AND USING SUCH BACTERIUM FOR MAKING VACCINE FOR ANIMAL OR HUMAN PROTECTION	2005	Lo Jujgan Vermehj Paul' Jakobs Antonius Arnol'Dus Kristian	RU2415926C2
DNA-VACCINE AGAINST TUMORAL GROWTH AND WAYS OF THEIR APPLICATION	2004	Sjan Zhun Chzhou Kheh Rejsfeld Ral'F A.	RU2343195C2
INTERLEUKIN-1 CONJUGATES AND THEIR APPLICATION	2006	Bakhmann Martin Shpon Gunter Tisso Alen	RU2441067C2
METHOD OF OBTAINING IMMUNOGENIC NON-HEMOLYTHIC BACTERIUM OF SPECIES Actinobacillus pleuropneumoniae, BACTERIUM OF SPECIES Actinobacillus pleuropneumoniae, VACCINE AGAINST PIG PLEUROPNEUMONIA (VERSIONS), IMMUNOGENIC AND NON-HAEMOLYTIC STRAIN OF Actinobacillus pleuropneumoniae (VERSIONS)	2003	Pin'Ol Ribas Khaume Bru Virkhili Serkhi Ehspun'Ja Maso Ehnrik Kerol Murill'O Ehnrike	RU2351360C2
VACCINE AGAINST NECROTIC ENTERITIS IN POULTRY	2018	Gun, Tszyankhua Lepp, Dion	RU2788096C2
GENE AND PROTEIN OF VIRULENCE AND THEIR USING	2000	Klark Ehnda Ehlizabet Zkhou Likuing Shia Zhaklin Ehlizabet Feldman Robert Grehkhehm Kholden Dehvid Vill'Jam	RU2240327C2

RU 2 593 945 C2

Authors

Kokren Mark D.

Petersen Geri

Lejr Stiven V.

Sinenki Richard

Dates

2016-08-10—Published

2007-04-12—Filed