FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, specifically to Wnt antagonists, and can be used in medicine. Using a signal sequence, Wnt-binding polypeptides based on domain Fri of human FZD8 and Fc-fragment are obtained. Produced polypeptides are used as part of a pharmaceutical composition for treating a disease associated with activation of Wnt signal transmission path, for example cancer.
EFFECT: invention increases homogeneity of mixture of Wnt-binding polypeptides when producing same by recombinant production.
32 cl, 21 dwg, 5 tbl, 17 ex
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