COMPOSITION AND METHOD OF PRODUCING EYE DROPS Russian patent published in 2016 - IPC A61K31/4704 C07D215/04 A61K47/38 A61K9/08 

FIELD: pharmaceutics.

SUBSTANCE: invention refers to pharmaceutics, particularly to ophthalmology, and invites methods of getting pharmaceutical compositions in the form of eye drops for local treatment of inflammatory eye diseases of microbial genesis and bacterial infections in humans and animals. Methods are characterized by the fact that an aqueous solution of methylcellulose according to method 1 or hydroxypropyl methylcellulose according to method 2 at a temperature of 80-90 °C with further cooling to room temperature. Preparation of a solution of boric acid at a temperature of 75-85 °C with further cooling to 50-60 °C, dissolving fluroquinolone compound and sodium chloride in a solution of boric acid with subsequent cooling to room temperature, introduction of an aqueous solution of methylcellulose, homogenization prepared solution, bringing the solution with sodium hydroxide to pH 6-8, carrying out steps of sterilizing filtration and aseptic filling; as an antibacterial fluroquinolone connection one of quinolone, namely lomefloxacin, or norfloxacin, or pefloxacin, or levofloxacin, or sparfloxacine, or moxifloxacin, or gatifloxacin, or gemifloxacin, or their acceptable salts.

EFFECT: preparing the pharmaceutical compositions.

2 cl, 9 tbl