COMPOSITION OF NANOSTRUCTURED APREPITANT, SYNTHESIS METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME Russian patent published in 2016 - IPC C07D413/06 A61K31/5377 A61P1/08

Abstract RU 2595841 C2

FIELD: nanotechnology.

SUBSTANCE: present invention is aimed at nanostructured aprepitant composition, method for production thereof and pharmaceutical compositions containing same. Nanoparticles of aprepitant according to invention have an average particle size of less than about 200 nm. Aprepitant is a chemical compound that belongs to a class of drugs called substance P antagonists (SPA). Its effect is mediated by action on neurokinin 1 receptor. Aprepitant is manufactured by Merck & Co. under brand name Emend for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) and for prevention of postoperative nausea and vomiting.

EFFECT: stable nanostructured particles of invention are presented by increased solubility, dissolution rate, permeability and bioequivalent or enhanced biological performance characterised by significantly decreased food effect compared to reference and marketed drug.

7 cl, 5 dwg, 6 ex

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RU 2 595 841 C2

Authors

Filipchei Genoveva

Etvesh Zholt

Kheltovich Gabor

Darvas Ferents

Dates

2016-08-27—Published

2011-06-17—Filed