NOVEL COMPOUNDS Russian patent published in 2016 - IPC C07D513/22 C07D487/22 A61K31/4738 A61K31/433 A61K31/519 A61K31/5025 A61P35/00 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a compound of formula I,

,

where ring A and ring B are condensed bicyclic group, R¹ denotes a substitute selected from hydrogen, halogen or OR^f7; each R^2a, R^2b, R^2c, R³ are independently selected from hydrogen, halogen, -CN, -OR^f7 or C_1-6 alkyl, optionally substituted with one or more substitutes selected from =O and E¹; X is a straight bond; Y denotes -arylene-, -heteroarylene-, where -arylene- and -heteroarylene- may be substituted with E³, where E³ denotes halogen, or -heterocycloalkylene-, optionally substituted with one or more substitutes selected from =O and E⁴, R^N denotes hydrogen or C_1-6 alkyl, optionally substituted with one or more substitutes selected from =O and E⁵; Z denotes -C(O)-[T¹]- or -C(O)N(R^x3)-[T¹]-, where T¹ denotes -(CH₂)_0-4-T²- and T² denotes a direct bond or -C(O)-N(H)-CH₂-; or its pharmaceutically acceptable ester, amide.

EFFECT: compounds are suitable for use in treating the diseases in which it is desirable and/or require inhibition of protein-or lipid-kinase (PI3-K, for example, especially class I PI3K kinase family, PIM and/or mTOR), and especially in treating cancer.

9 cl, 1 dwg, 4 tbl