FIELD: biotechnology.
SUBSTANCE: invention relates to a live attenuated recombinant poliovirus, use thereof to produce vaccines, as an inoculum or for preparing a drug, a method of producing such a vaccine and a method of vaccinating a patient. Described poliovirus has a 5' non-coding region consisting of the 5' non-coding region of Sabin 3, modified so that it does not have a base pair mismatch in stem (a) or (b) of domain V, wherein seven or eight of base pairs in stems (a) and (b) are U-A or A-U base pairs; and a capsid protein from Sabin 1, Mahoney, MEF or Saukett strain.
EFFECT: presented inventions can be used to produce safe vaccines with improved immunogenic properties against poliovirus.
14 cl, 4 dwg, 7 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMBINED VACCINE CONTAINING DIPHTHERIA, TETANUS, ACELLULAR PERTUSSIS, HAEMOPHILUS INFLUENZAE AND POLIOVIRUS ANTIGENS, USING IT AND METHOD FOR PREPARING IT | 2009 |
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RU2526214C2 |
| COMBINED VACCINE WITH ACELLULAR PERTUSSIS | 2013 |
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| COMBINED VACCINE WITH WHOLE-CELL PERTUSSIS COMPONENT | 2011 |
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| COMBINED VACCINE WITH WHOLE-CELL PERTUSSIS COMPONENT | 2009 |
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RU2504398C2 |
| AGENT FOR ESTIMATION OF POLIOMYELITIS VIRUS ATTENUATION DEGREE | 1992 |
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| RECOMBINANT FLAVIVIRAL VACCINES | 2006 |
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RU2465326C2 |
| COMBINED HEPTAVALENT VACCINE | 2012 |
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| METHOD OF INTRA-TYPE DIFFERENTIATION OF POLYO VIRUSES | 0 |
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SU1583441A1 |
| MULTIPLE VACCINATION INCLUDING SEROGROUP C MENINGOCOCCI | 2006 |
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RU2457858C2 |
| POLYVALENT ASSOCIATED DIPHTHERIA, TETANUS TOXOIDS AND PERTUSSIS POLIOVIRUS VACCINES | 1997 |
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RU2194531C2 |
