FIELD: medicine.
SUBSTANCE: chimeric flavivirus contains at least one mutation in a coat protein of chimeric flavivirus, and one or more mutations in (i) 3'-untranslated region (3'-UTR) of a chimeric flavivirus genome and/or (ii) a capside protein of chimeric flavivirus.
EFFECT: chimeric flavivirus shows reduced viscerotropism as compared to mutation-free chimeric flavovirus; virus is completely attenuated.
32 cl, 8 dwg, 7 tbl
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| METHOD OF VIRUS ATTENUATION | 1998 |
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