FIELD: medicine.
SUBSTANCE: chimeric flavivirus contains at least one mutation in a coat protein of chimeric flavivirus, and one or more mutations in (i) 3'-untranslated region (3'-UTR) of a chimeric flavivirus genome and/or (ii) a capside protein of chimeric flavivirus.
EFFECT: chimeric flavivirus shows reduced viscerotropism as compared to mutation-free chimeric flavovirus; virus is completely attenuated.
32 cl, 8 dwg, 7 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| CHIMERIC FLAVIVIRAL VACCINES | 1998 |
|
RU2209082C2 |
| VACCINE AGAINST VIRUS OF WEST NILE ENCEPHALITIS | 2003 |
|
RU2376374C2 |
| CHIMERIC VACCINES BASED ON VIRUSES OF FLAVIVIRUS AND LYSSAVIRUS GENES | 2019 |
|
RU2816136C2 |
| LYOPHILISED COMPOSITION FOR INDUCING IMMUNE RESPONSE TO FLAVIVIRUS, COMPOSITION AND METHOD FOR PREPARING IT | 2007 |
|
RU2541784C2 |
| FLAVIVIRUS WITH BIPARTITE GENOME AND USING IT | 2008 |
|
RU2527891C2 |
| METHOD OF VIRUS ATTENUATION | 1998 |
|
RU2202357C2 |
| IMMUNOBIOLOGICAL AGENT FOR THE PREVENTION OF DISEASES CAUSED BY TICK-BORNE ENCEPHALITIS VIRUS BASED ON A RECOMBINANT VIRUS OF THE GENUS FLAVIVIRUS | 2022 |
|
RU2795800C1 |
| INACTIVATED CHIMERIC VACCINES AND RELATED METHODS OF APPLICATION | 2006 |
|
RU2436591C2 |
| LIVING ATTENUATED STRAIN OF YELLOW FEVER VIRUS, ADAPTED TO GROWTH IN VERO CELLS, AND VACCINE COMPOSITION CONTAINING IT | 2019 |
|
RU2788130C2 |
| DNA-CONSTRUCT OF VIABLE CHIMERIC RECOMBINANT FLAVIVIRUS AGAINST TICK-BORNE ENCEPHALITIS VIRUS, METHOD OF PROPHYLAXIS OF INFECTION MAMMAL WITH TICK-BORNE ENCEPHALITIS VIRUS | 1998 |
|
RU2208635C2 |
