FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-ene-1-yl]piperazine (flunarizine). Core of invention is that flunarizine is obtained form a Fe-catalyzed combination of 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-chloroprop-2-ene-1-yl]piperazine obtained by allylation of 1-[bis(4-fluorophenyl)methyl]piperazine with industrially available (E)-1,3-dichloropropene with phenylmagnesium-halogenide in an aprotic solvent in an inert gas atmosphere in presence of an iron salt.
EFFECT: high output of flunarizine (up to 89 %), reduced cost of the process and lower toxicity of the catalyst.
5 cl, 5 ex
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