FIELD: chemistry.
SUBSTANCE: invention relates to method of obtaining (E)-1-(diphenylmethyl)-4-(3-phenylprop-2-en-1-yl)piperazine (cinnarizine). Method consists in Fe-catalysed combination of 1-[(2E)-3-chloroprop-2-en-1-yl]-4-(diphenylmethyl)piperazine, with phenylmagnesiumhalogenide in aprotic solvent in inert gas atmosphere in presence of iron (III) salt.
EFFECT: high output of cinnarizine, low cost and low toxicity of catalyst.
6 cl, 6 ex
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