FIELD: medicine.
SUBSTANCE: invention relates to tumour therapy. In one aspect, the present invention relates to conjugates of an amatoxin and a target-binding moiety, for example, an antibody, connected by a linker comprising a urea moiety, which are useful in the treatment of cancer. In a further aspect the invention relates to pharmaceutical compositions comprising such conjugates, and a method for synthesizing said conjugates.
EFFECT: conjugates that are stable in plasma, so that harmful side effects to non-target cells are minimized.
14 cl, 9 dwg, 6 ex
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